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New plant extracts can be powerful against HIV infection

2019-08-29 11:44:04

Recently, a research report published in the international journal Journal of Natural Products, researchers from the University of Illinois and other institutions found that a plant from Southeast Asia for the treatment of arthritis and rheumatism may contain a A potential anti-HIV compound that is more potent than the drug zidovudine (AZT); in the article, the researchers screened more than 4,500 plant extracts and finally screened out the compound called patentiflorin A, which From the bed of Willow, it can help fight HIV effectively.

The study found that the results of many years of collaboration between multiple research institutions, the researchers through the screening of a number of natural products that have useful applications in the health of the body, eventually found this new anti-HIV compounds, and researchers hope that this compound Can significantly improve the health of people in low-income countries.

The study found that the results of many years of collaboration between multiple research institutions, the researchers through the screening of a number of natural products that have useful applications in the health of the body, eventually found this new anti-HIV compounds, and researchers hope that this compound Can significantly improve the health of people in low-income countries.

The extract of Willow's bed usually comes from the leaves, stems and roots of plants. The researchers collected these plants in the Jufang National Park in Hanoi. The researchers analyzed thousands of plant extracts to identify which extracts can effectively resist. HIV, tuberculosis, malaria and cancer. Eventually they locked the compound patentiflorin A, a compound that effectively inhibits the key enzymes needed for HIV, which helps HIV insert the virus's own genetic code into the host cell's DNA, AZT, developed by researchers in 1987. The first anti-HIV drug is still an important drug for the treatment of HIV. AZT is able to inhibit the reverse transcriptase of the virus. After studying human cells infected with HIV, the researchers found that patentiflorin A can significantly inhibit the reverse transcriptase of the virus.

Researcher Rong said that the compound patentiflorin A significantly inhibits the activity of viral reverse transcriptase compared to the drug ZAT, and whether the virus enters the early stages of macrophages or is present in immune system T cells, the compound Both can play a good role. At the same time, this new compound can also effectively resist drug-resistant HIV strains, which may help researchers develop new HIV drugs in the future. Of course, this compound may also be added as a novel anti-HIV preparation to the current anti-HIV drug mixture to effectively increase the inhibition of the virus and the preventive effect of AIDS.

Finally, the researchers said that they can now synthesize patentiflorin A. If the compound can be synthesized in the laboratory, it may not be necessary to establish a farm to raise the corresponding plants (the willow bed), which will greatly reduce the financial The investment, and of course more importantly, this new compound has shown great potential and value in combating HIV infection, and later researchers will use more in-depth research to elucidate the mechanism of action of patentiflorin A against HIV.

 

Source: Bio Valley

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